History and possible effects of substituted Amphetamines

The compounds in this class span a variety of pharmacological subclasses, including stimulants, empathogens, and hallucinogens, among others. Examples of substituted amphetamines are amphetamine (itself), methamphetamine, ephedrine, cathinone, phentermine, mephentermine, bupropion, methoxyphenamine, selegiline, amfepramone, pyrovalerone, MDMA (ecstasy), and DOM (STP).

Some of amphetamine’s substituted derivatives occur in nature, for example in the leaves of Ephedra and khat plants which have been used by humans for more than 1000 years for their pharmacological effect. Amphetamine was first produced at the end of the 19th century. By the 1930s, amphetamine and some of its derivative compounds found use as decongestants in the symptomatic treatment of colds and also occasionally as psychoactive agents. Their effects on the central nervous system are diverse, but can be summarized by three overlapping types of activity: psychoanaleptic, hallucinogenic and empathogenic. Various substituted amphetamines may cause these actions either separately or in combination.

Over-the-counter use of substituted amphetamines was initiated in the early 1930s by the pharmaceutical company Smith, Kline & French (now part of GlaxoSmithKline), as a medicine (Benzedrine) for colds and nasal congestion. Subsequently, amphetamine was used in the treatment of narcolepsy, obesity, hay fever, orthostatic hypotension, epilepsy, Parkinson’s disease, alcoholism and migraine. The “reinforcing” effects of substituted amphetamines were quickly discovered, and the misuse of substituted amphetamines had been noted as far back as 1936.

Structure of substituted Amphetamines

Substituted amphetamines are a class of compounds that have structures based on that of amphetamine with different substitutions at various positions. An amphetamine molecule has the structure of a phenethylamine molecule with an additional methyl group located on the alpha carbon. Thus, in addition to being the unsubstituted member of the substituted amphetamine class, amphetamine is also considered a substituted phenethylamine.

Substituted Amphetamines properties

You can buy substituted Amphetamines online through our shop, RareChems, in powder, blotter or pellet form for research purposes. Psychoactive substances of the substituted amphetamine class typically produce effects through dopaminergic, serotonergic, and adrenergic pathways. Psychedelic effects can be attributed to action on the 5-HT2A receptor. Stimulant and entactogenic effects are due to their action as releasing agents of dopamine, serotonin, epinephrine and norepinephrine or as agonists on the receptors of the previous neurotransmitters. The agonism of this set of receptors leads to an increased rate firing of the post-synaptic neuron, triggering both cognitive and physical stimulation within the user.

You can find more info inside the Psychonaut page.

About substituted Phenylmorpholines

Substituted phenylmorpholines, or substituted phenmetrazines alternatively, are chemical derivatives of phenylmorpholine or of the psychostimulant drug phenmetrazine. Most such compounds act as releasers of monoamine neurotransmitters, and have stimulant effects. Some also act as agonists at serotonin receptors, and compounds with an N-propyl substitution act as dopamine receptor agonists. A number of derivatives from this class have been investigated for medical applications, such as for use as anorectics or medications for the treatment of ADHD.

You can buy substituted Phenylmorpholines online through our shop, RareChems, in powder, blotter or pellet form for research purposes.

You can find more info in the wikipedia page.

About substituted Phenidates

Substituted phenidates (also known as phenidates) refer to a class of compounds that predominantly produce traditional stimulant effects when administered. A substituted phenidate may be defined as an ester of ritalinic acid and its analogs.

Structure of substituted Phenidates

Substituted phenidates are a chemical class based upon the molecule methylphenidate. The molecular structure of methylphenidate is comprised of a phenethylamine core with a carbon chain substitution at the Rα position that links to the RN position, forming a piperidine ring. It also includes a substitution at the Rβ position of methyl acetate.

Substituted Phenidates properties

You can buy substituted Phenidates online through our shop, RareChems, in powder, blotter or pellet form for research purposes. Substituted phenidates primarily act as reuptake inhibitors of the monoamine neurotransmitters dopamine, norepinephrine, and to a much lesser degree, serotonin. One study found that all substituted phenidates inhibited the norepinephrine and dopamine reuptake transporters 4 to >1,000-fold more potently than the serotonin transporter.

You can find more info inside the Psychonaut page.

Special terms and conditions to buy substituted Amphetamines, substituted Phenylmorpholines or substituted Phenidates

All our research chemicals, including substituted Amphetamines, substituted Phenylmorpholines or substituted Phenidates, are strictly sold for laboratory and analytic purposes only. If you purchase our offered products from outside of the Netherlands, please check the legal status in your country before ordering since you’re responsible for compliance with the laws of your jurisdiction.

If you want to be sure a research chemical of the substituted Amphetamines, substituted Phenylmorpholines or substituted Phenidates families is available for your country, please read the product description. Another way would be to create an account with us and insert your shipping address in your account. That way, if the product is blocked for your country, the system won’t allow you to add it to your cart.

Depending on the country of destination, you’ll have the option to select the airmail shipping method and the registered airmail one, which is trackable and it’s insured by us in the case of lost. Also, the payment method depends on the country of destination, where you should be able to pay using cryptocurrencies like Bitcoin, Litecoin, Ethereum and Monero between others, and by bank transfer in some cases.

Once we receive the payment, your order with substituted Amphetamines, substituted Phenylmorpholines or substituted Phenidates will be set to accepted and we will send you a new email notification. If the payment is received before 16h (CET), your order will be dispatched the next day.

Note: Some products related to this category might be provided in pellet and/or blotter form only, and therefore not listed under this category. Please check the BLOTTER and PELLET categories as well.